DETAILS, FICTION AND METHADONE CLINIC NURSE JOBS

[61] Like a lot of other cardiotoxic drugs, methadone blocks the hERG K+ channel. The two enantiomers of methadone inhibit hERG channels with diverse potency. Dextromethadone, that's considerably less powerful being an opioid, is much more strong at blocking the hERG channel with an IC50 of ~12 μM. Levomethadone provides a lower affinity, with an